Widely used as a bulky, electron-rich ligand in transition metal catalysis, this compound plays a key role in palladium-catalyzed cross-coupling reactions. It enhances catalytic activity and stability, especially in challenging transformations such as the Suzuki–Miyaura and Buchwald–Hartwig aminations. Its steric bulk and strong donor properties promote oxidative addition and reductive elimination steps, enabling efficient coupling of sterically hindered or electronically deactivated substrates. It is particularly effective in forming carbon–carbon and carbon–heteroatom bonds under mild conditions, making it valuable in pharmaceutical and agrochemical synthesis where complex molecules require selective and robust catalytic systems.