Widely used in palladium-catalyzed cross-coupling reactions, this phosphine ligand enhances catalyst stability and reactivity, particularly in Buchwald–Hartwig aminations and Suzuki–Miyaura couplings. Its steric bulk and electron-donating properties promote efficient turnover with high selectivity, even at low catalyst loadings. It is especially valued in pharmaceutical synthesis where mild reaction conditions and functional group tolerance are critical. The ligand also supports coupling of challenging substrates such as aryl chlorides, which are less reactive than bromides or iodides. Its performance in air-sensitive reactions is improved when handled under inert atmosphere, though it is more stable than many phosphine ligands. Commonly employed in the preparation of complex organic molecules, including drug intermediates and functional materials.