Tetramethyl tBuXPhos is widely used as a ligand in transition metal-catalyzed reactions, particularly in cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig amination. Its sterically demanding and electron-rich properties enhance the efficiency and selectivity of these catalytic processes, making it valuable in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. Additionally, it is employed in the development of complex organic molecules, where precise control over reaction pathways is critical. Its stability and performance under various reaction conditions make it a preferred choice in both academic research and industrial applications.