Di-1-adamantylphosphine is primarily used as a ligand in organometallic chemistry and catalysis. Its bulky adamantyl groups make it highly effective in stabilizing low-coordinate metal centers, which is crucial in various catalytic processes. This compound is particularly valuable in the development of catalysts for cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, where it enhances reaction efficiency and selectivity. Additionally, its steric bulk can prevent unwanted side reactions, making it useful in the synthesis of complex organic molecules. Di-1-adamantylphosphine is also explored in materials science for creating advanced polymers and coordination complexes with unique properties.