Tris(2,4-dimethylphenyl)phosphine is primarily used as a ligand in coordination chemistry and catalysis. It plays a significant role in the synthesis of organometallic compounds, particularly in transition metal-catalyzed reactions. Its sterically hindered structure makes it effective in stabilizing metal complexes, enhancing selectivity and efficiency in processes such as cross-coupling reactions, hydrogenation, and polymerization. Additionally, it is utilized in the development of advanced materials, including phosphorescent compounds for organic light-emitting diodes (OLEDs). Its application extends to pharmaceutical research, where it aids in the creation of complex molecular structures through precise catalytic processes.