SHP099 hydrochloride is primarily used in biochemical research as a potent and selective inhibitor of SHP2, a protein tyrosine phosphatase involved in various cellular signaling pathways. Its application is significant in studying cancer biology, as SHP2 plays a critical role in oncogenic signaling pathways such as RAS-ERK, making it a potential target for cancer therapy. Researchers utilize this compound to investigate its effects on tumor growth, metastasis, and resistance to treatments. Additionally, it is employed in preclinical studies to explore its efficacy in combination therapies with other anticancer agents. Its role in modulating immune responses is also under investigation, particularly in the context of immunotherapy for cancer.