NSC-87877 is primarily utilized in biochemical research as a potent and selective inhibitor of SHP-2 phosphatase, an enzyme involved in various cellular signaling pathways. Its application is significant in studying the role of SHP-2 in cancer development, as it helps researchers understand how inhibition of this enzyme affects tumor growth and metastasis. Additionally, NSC-87877 is used in experiments exploring immune system regulation, as SHP-2 plays a role in immune cell signaling. Its ability to modulate these pathways makes it a valuable tool in drug discovery and the development of targeted therapies for diseases linked to SHP-2 dysfunction.