TPI-1 is primarily utilized in research settings, particularly in the study of cellular signaling pathways. It acts as a selective inhibitor of T-cell protein tyrosine phosphatase (TCPTP), making it a valuable tool for investigating the role of TCPTP in immune responses and metabolic regulation. Researchers use TPI-1 to explore its effects on insulin signaling, inflammation, and autoimmune diseases, as TCPTP is known to modulate these processes. Additionally, TPI-1 is employed in preclinical studies to understand its potential therapeutic applications in conditions like diabetes and cancer, where TCPTP activity is implicated. Its ability to selectively target TCPTP allows for precise manipulation of cellular pathways, aiding in the development of targeted therapies.