NSC87877 is primarily utilized in biochemical research as a potent and selective inhibitor of SHP-2 phosphatase, an enzyme involved in various cellular signaling pathways. Its application is significant in studying cancer biology, as SHP-2 plays a role in oncogenic signaling and tumor progression. Researchers use NSC87877 to investigate the mechanisms of SHP-2 in cell proliferation, differentiation, and survival, providing insights into potential therapeutic targets for cancer treatment. Additionally, it is employed in drug discovery efforts to develop novel inhibitors for diseases linked to SHP-2 dysregulation. Its specificity makes it a valuable tool for understanding the role of phosphatases in cellular processes and disease states.