Tetramethyl Nordihydroguaiaretic Acid is primarily used in research settings to study its antioxidant properties. It is often employed in biochemical assays to investigate its ability to inhibit lipid peroxidation, which is crucial in understanding oxidative stress-related diseases. Additionally, it serves as a reference compound in the development of antioxidants for potential therapeutic applications. In material science, it is explored for its potential to stabilize polymers and other materials susceptible to oxidative degradation. Its role in modulating enzyme activity, particularly in pathways involving oxidative enzymes, is also a significant area of study.