Polyisobutylene is widely used as a key component in the production of adhesives and sealants due to its excellent tackiness and flexibility. It is commonly found in pressure-sensitive adhesives, such as those used in tapes and labels, where it provides strong bonding properties. In the automotive industry, it is utilized in the manufacturing of inner liners for tires, enhancing air retention and durability. Additionally, it serves as an additive in lubricants and fuels to improve viscosity and performance. In construction, it is applied in waterproofing membranes and coatings to prevent moisture penetration. Its chemical resistance also makes it suitable for use in industrial gaskets and O-rings.

Furthermore, in the food industry, it is used in chewing gum as a non-sticky elastomeric base. In pharmaceuticals, it acts as a coating agent or processing aid. It is also employed in medical applications such as bandages and tubes, as well as in thermal insulation materials.