Hydrocortisone-17-butyrate is primarily used in dermatology for its potent anti-inflammatory and anti-itch properties. It is applied topically to treat various skin conditions such as eczema, dermatitis, psoriasis, and allergic reactions. The compound helps reduce redness, swelling, and itching by suppressing the immune response in the affected area. It is particularly effective for managing chronic skin conditions and is often prescribed for short-term use to avoid potential side effects like skin thinning. Additionally, it is suitable for sensitive skin areas, including the face and flexures, due to its balanced potency and reduced risk of irritation. Proper application and adherence to prescribed guidelines ensure optimal therapeutic outcomes.