Nomegestrol acetate is primarily used in hormonal contraceptives, particularly in combination with estrogen, to prevent pregnancy. It is a key component in oral contraceptive pills, offering high efficacy and good cycle control. Additionally, it is utilized in hormone replacement therapy (HRT) to manage symptoms of menopause, such as hot flashes and vaginal atrophy, by providing a progestogenic effect. Its anti-androgenic properties make it beneficial in treating conditions like acne, hirsutism, and other androgen-dependent disorders. Nomegestrol acetate is also studied for its potential role in managing endometriosis and menstrual disorders due to its ability to regulate hormonal imbalances. Its favorable safety profile and tolerability make it a widely accepted option in hormonal treatments.