Nomegestrol acetate is primarily used in hormonal contraceptives, particularly in combination with estrogen, to prevent pregnancy by mimicking progesterone and inhibiting ovulation. It is effective in regulating the menstrual cycle and reducing symptoms associated with hormonal imbalances, such as heavy or irregular periods and severe dysmenorrhea. Additionally, it is utilized in hormone replacement therapy (HRT) for menopausal women to alleviate symptoms like hot flashes, night sweats, and vaginal dryness. It is also used in the treatment of endometriosis. Its anti-androgenic properties make it beneficial in treating conditions like acne and hirsutism in women. Nomegestrol acetate is also being studied for its potential role in managing certain hormone-dependent cancers, such as breast cancer, due to its ability to modulate hormone receptors.