Gestodene is primarily used as a key active component in hormonal contraceptives, particularly in combination oral contraceptive pills. It works by inhibiting ovulation, altering the cervical mucus to impede sperm penetration, and changing the endometrium to reduce the likelihood of implantation.

In addition to its contraceptive use, gestodene is sometimes employed in hormone replacement therapy (HRT) to manage symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis. Its progestogenic activity helps balance estrogen effects, reducing the risk of endometrial hyperplasia.

Gestodene is also utilized in the treatment of menstrual disorders, including irregular cycles, heavy menstrual bleeding, and dysmenorrhea. Its ability to regulate hormonal fluctuations contributes to more predictable and manageable menstrual cycles.

Due to its potent progestogenic properties, gestodene is often chosen for its efficacy and lower dose requirements, minimizing side effects while maintaining high contraceptive reliability.