Dofetilide
≥98%
Reagent
Code: #77581
CAS Number
115256-11-6
science Other reagents with same CAS 115256-11-6
blur_circular Chemical Specifications
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Molecular Information
Weight
441.56 g/mol
Formula
C₁₉H₂₇N₃O₅S₂
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Registry Numbers
MDL Number
MFCD00006064
thermostat
Physical Properties
Melting Point
164 °C
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Storage & Handling
Storage
room temperature
description Product Description
Dofetilide (CAS No. 115256-11-6; chemical formula C19H26N2O5S2) is a specialty chemical and class III antiarrhythmic agent. It is primarily used in the management of atrial fibrillation and atrial flutter by selectively blocking the rapid component of the delayed rectifier potassium current (IKr) in cardiac cells, helping to restore and maintain normal sinus rhythm. This pharmaceutical intermediate is particularly effective for patients refractory to other antiarrhythmics. Due to the risk of QT prolongation and torsades de pointes, initiation requires inpatient monitoring. Dofetilide is administered orally, with dosing adjusted based on renal function (creatinine clearance).
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | Pale yellow powder |
| Purity | 97.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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