Phosphomycin calcium is widely used in the treatment of bacterial infections, particularly those caused by susceptible strains of bacteria. It is effective against urinary tract infections (UTIs), including cystitis and pyelonephritis, due to its ability to concentrate in the urine. The antibiotic is also utilized in veterinary medicine for treating bacterial infections in animals. Its broad-spectrum activity makes it a valuable option for combating gram-positive and gram-negative bacteria. Additionally, it is sometimes employed as a prophylactic measure to prevent infections during surgical procedures. The calcium salt form enhances its stability and bioavailability, making it suitable for oral administration. Its mechanism of action, which involves inhibiting bacterial cell wall synthesis, ensures it remains effective against resistant strains, contributing to its role in modern antimicrobial therapy.