Metoclopramide hydrochloride is primarily used to treat gastrointestinal disorders. It is effective in managing nausea and vomiting, particularly those caused by chemotherapy, radiation therapy, or surgery. The drug works by speeding up stomach emptying, making it useful for conditions like gastroparesis, where the stomach muscles do not function properly. It is also prescribed for reflux esophagitis to reduce symptoms of heartburn and acid reflux. In some cases, it is used to assist in diagnostic procedures of the upper gastrointestinal tract by enhancing the movement of contrast agents. Additionally, it can help alleviate migraine-related nausea when other treatments are not effective. Always consult a healthcare professional for appropriate use and dosage.