Pamidronate Disodium is primarily used in the treatment of bone-related conditions. It is effective in managing hypercalcemia, a condition characterized by abnormally high calcium levels in the blood, often associated with malignancies. The drug works by inhibiting bone resorption, thereby reducing calcium release into the bloodstream.

It is also utilized in the treatment of Paget's disease, a chronic disorder that can result in enlarged and misshapen bones. By slowing down the excessive bone breakdown and formation, Pamidronate Disodium helps alleviate pain and reduce the risk of complications such as fractures and deformities.

Additionally, it is employed in the management of osteoporosis, particularly in patients who cannot tolerate other bisphosphonates. It helps increase bone density and reduce the risk of fractures in individuals with this condition.

In oncology, Pamidronate Disodium is used to prevent skeletal-related events in patients with bone metastases from cancers such as breast cancer and multiple myeloma. It helps strengthen bones, reduce pain, and lower the incidence of pathological fractures, spinal cord compression, and the need for radiation or surgery to the bone.

Overall, Pamidronate Disodium plays a crucial role in improving the quality of life for patients with various bone disorders and cancer-related bone complications.