Cefamandole nafate is primarily used as an antibiotic in the treatment of various bacterial infections. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a versatile choice for healthcare providers.

In clinical settings, it is often administered to treat respiratory tract infections, such as pneumonia and bronchitis, where bacterial involvement is confirmed. It is also utilized in managing urinary tract infections, skin and soft tissue infections, and bone and joint infections.

Additionally, cefamandole nafate is employed in surgical prophylaxis to prevent postoperative infections, particularly in procedures involving the gastrointestinal tract, cardiovascular system, or orthopedic surgeries. Its broad-spectrum activity helps reduce the risk of infection during and after surgery.

In cases of septicemia or bloodstream infections, this antibiotic is sometimes chosen due to its ability to combat a variety of pathogens. It is typically administered intravenously or intramuscularly to ensure rapid and effective delivery to the bloodstream.

Overall, cefamandole nafate plays a critical role in combating bacterial infections and preventing complications in both medical and surgical contexts.