Tibolone is primarily used in hormone replacement therapy (HRT) for postmenopausal women. It helps alleviate symptoms associated with menopause, such as hot flashes, night sweats, and vaginal dryness. Additionally, it aids in preventing bone loss, reducing the risk of osteoporosis in this demographic. Tibolone also has a positive impact on mood and libido, improving overall quality of life for women experiencing hormonal changes. Its unique mechanism of action allows it to act as an estrogen, progesterone, and androgen receptor modulator, providing a balanced hormonal effect. However, it is not suitable for all women, particularly those with a history of certain cancers or cardiovascular conditions, and should be used under medical supervision.