Guanabenz acetate is primarily used as an antihypertensive agent, helping to manage high blood pressure by stimulating alpha-2 adrenergic receptors in the brain. This action reduces the release of norepinephrine, leading to decreased peripheral vascular resistance and ultimately lowering blood pressure. It is often prescribed for patients who require long-term blood pressure control and may be used in combination with other antihypertensive medications for enhanced efficacy. Additionally, guanabenz acetate has shown potential in research studies for its neuroprotective properties, particularly in conditions like amyotrophic lateral sclerosis (ALS), where it may help reduce cellular stress and improve neuron survival. Its ability to modulate stress responses in cells has also sparked interest in exploring its use in other neurodegenerative diseases.