Silibinin is widely used for its hepatoprotective properties, making it a key agent in supporting liver health. It is commonly employed in the treatment of liver disorders such as alcoholic liver disease, viral hepatitis, and toxin-induced liver damage. Due to its strong antioxidant activity, silibinin helps neutralize free radicals and reduces oxidative stress in liver tissues. It also exhibits anti-inflammatory effects by inhibiting pro-inflammatory signaling pathways. In addition to liver support, silibinin has shown promise in cancer research. It has been studied for its ability to inhibit the growth of various cancer cells, including those of the prostate, skin, and colon, by interfering with cell cycle progression and promoting apoptosis. Silibinin is also used in dermatology, particularly in topical formulations, to protect the skin from UV radiation damage and to support the treatment of skin conditions like melasma and photoaging. Its ability to stabilize cell membranes and modulate cellular signaling contributes to its protective role in both internal and external applications.