Widely used in the treatment of second- and third-degree burns, this chemical helps prevent infection in open wounds by providing broad-spectrum antimicrobial activity against bacteria, including Pseudomonas aeruginosa, through inhibition of microbial growth by disrupting folic acid synthesis. It is commonly applied topically in burn units due to its ability to reduce sepsis risk and support wound healing. Its sustained release formulation allows for once- or twice-daily application, improving patient compliance. It is also used in skin grafts and chronic ulcers where infection control is critical. Due to its local action and minimal systemic absorption, it is considered safe for prolonged use in most patients, though monitoring is advised in those with sulfonamide sensitivity.