Widely used in bioseparation and diagnostic applications due to their uniform size and strong magnetic response. The silica shell provides a stable, biocompatible surface that can be easily modified with functional groups for covalent binding of biomolecules such as antibodies, DNA, or enzymes. These microspheres are ideal for automated high-throughput systems in molecular biology, including nucleic acid purification, protein isolation, and cell separation. Their core-shell structure enhances magnetic responsiveness while maintaining colloidal stability, allowing rapid separation under a magnetic field with minimal non-specific binding. Commonly employed in point-of-care testing, liquid biopsy, and targeted drug delivery research due to their reproducibility and scalability.