Used in bioseparation and diagnostic applications due to their uniform size and magnetic responsiveness. The silica shell allows easy surface modification with functional groups for binding biomolecules such as DNA, RNA, proteins, and antibodies. Commonly applied in automated high-throughput systems for nucleic acid purification, immunoassays, and cell isolation. Their core-shell structure enhances magnetic sensitivity while maintaining colloidal stability, making them ideal for use in microfluidic devices and point-of-care testing. Also employed in drug delivery research and targeted therapy due to their biocompatibility and ability to be guided by external magnetic fields.