Rhein is widely used in pharmaceutical and cosmetic industries due to its biological activities. It exhibits anti-inflammatory and antioxidant properties, making it valuable in treating skin conditions such as psoriasis and acne. In traditional medicine, rhein is employed to support liver and kidney function and has been studied for its potential in managing diabetes by improving insulin sensitivity. It also shows laxative effects and is used in herbal formulations for constipation relief. Recent research explores its role in cancer therapy, where it may inhibit tumor cell growth and induce apoptosis. Additionally, rhein is investigated for its protective effects in neurodegenerative diseases due to its ability to reduce oxidative stress in neural tissues.