rel-(2R,3S)-2-(2,4-Difluorophenyl)-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
97%
Reagent
Code: #228979
CAS Number
182369-73-9
blur_circular Chemical Specifications
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Molecular Information
Weight
331.32 g/mol
Formula
C₁₆H₁₅F₂N₅O
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Registry Numbers
MDL Number
MFCD24387076
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Physical Properties
Boiling Point
513.3±60.0 °C(Predicted)
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Storage & Handling
Density
1.37±0.1 g/cm3(Predicted)
Storage
-20°C, Sealed
description Product Description
This compound is a key intermediate in the synthesis of azole antifungal agents, particularly for producing drugs that inhibit ergosterol synthesis, a critical component of fungal cell membranes, resulting in membrane instability and fungal cell death. It plays an essential role in the pharmaceutical industry for developing treatments against systemic and superficial fungal infections, including those caused by Candida and Aspergillus species, especially in immunocompromised patients. Its specific stereochemistry enhances the efficiency of the synthesis process. The purity and quality of this intermediate directly influence the efficacy and safety of the final antifungal medications, which are commonly formulated for oral and intravenous administration.
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