Used primarily in ophthalmic formulations due to its enhanced corneal penetration. It acts as a prodrug, converting to prednisolone in ocular tissues, providing potent anti-inflammatory effects. Commonly found in eye drops for treating inflammation of the eye and surrounding structures, such as post-surgical inflammation, allergic conjunctivitis, and uveitis. The 17-ethylcarbonate modification improves lipid solubility, allowing better absorption through the cornea while minimizing systemic exposure.