Widely used in veterinary medicine, oxfendazole is effective against a broad spectrum of gastrointestinal parasites, including roundworms, lungworms, and certain tapeworms. It is commonly administered to livestock such as cattle, sheep, and pigs to control infections that reduce productivity and cause disease. The compound works by inhibiting tubulin polymerization in parasites, leading to their death. Oxfendazole is also being investigated for use in humans, particularly in the treatment of neglected tropical diseases like cystic echinococcosis and neurocysticercosis. Its ability to cross the blood-brain barrier makes it a candidate for targeting parasitic cysts in the central nervous system. In aquaculture, it has shown potential in managing parasitic infections in farmed fish, contributing to improved health and yield. Due to its residual activity and persistence in tissues, careful withdrawal periods are observed in food-producing animals to ensure food safety.