[Met(O)14]-Exenatide is the methionine sulfoxide analog of Exenatide, featuring oxidation at the 14th position. It serves as an analytical reference standard and impurity marker in pharmaceutical quality control for Exenatide formulations used in type 2 diabetes treatment. Exenatide is a GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, lowers blood glucose, suppresses appetite, and delays gastric emptying to promote weight loss. Administered subcutaneously as an adjunct to diet and exercise, it is also investigated for neuroprotective and anti-inflammatory effects in neurodegenerative diseases and NASH. This oxidized form is primarily utilized in research and analytical applications to assess stability and degradation.