Josamycin is used primarily as an antibiotic to treat bacterial infections, especially those caused by Gram-positive bacteria. It is effective in treating respiratory tract infections, such as bronchitis and pneumonia, as well as skin and soft tissue infections. It is also used in the management of upper respiratory infections like tonsillitis and pharyngitis. Due to its favorable tissue penetration and low toxicity, josamycin is often prescribed in pediatric and adult populations where penicillin allergy is a concern. It works by inhibiting bacterial protein synthesis, thereby stopping the growth of susceptible microorganisms.