2-Iodohippuric acid is used as a precursor for radiolabeled compounds in nuclear medicine, particularly for renal function studies and imaging. When labeled with iodine-131 or iodine-125, it assesses effective renal plasma flow through glomerular filtration and tubular secretion, aiding in the detection of urinary tract obstructions or impairments. Its structural similarity to hippuric acid enables it to follow analogous metabolic pathways, serving as a reliable tracer for organic anion transport in the nephron.