Used as a key reagent in organic synthesis, particularly in phosphorylation reactions. It enables the introduction of phosphinyl groups into organic molecules, making it valuable in the development of pharmaceuticals, agrochemicals, and biologically active compounds. Its reactivity allows for the formation of carbon-phosphorus bonds under mild conditions, which is advantageous in constructing complex molecules. Commonly applied in the synthesis of phosphonate esters, which serve as analogs of phosphate esters in medicinal chemistry for enzyme inhibition studies. Also utilized in the preparation of ligands for catalysts in transition metal-catalyzed reactions.