Used in the treatment of atrial fibrillation and atrial flutter, dofetilide helps restore and maintain normal sinus rhythm. It is prescribed for patients with symptomatic arrhythmias, particularly those with normal ventricular function. Due to its specific action on cardiac ion channels, it is carefully dosed and monitored, often requiring initial administration in a hospital setting to watch for potential proarrhythmic effects. Dofetilide offers an option for rhythm control without significant negative inotropic effects, making it suitable for patients with preserved heart function.