Used primarily to treat high blood pressure by stimulating alpha-adrenergic receptors in the brain, leading to reduced sympathetic outflow and lowered heart rate and vascular resistance. Also prescribed for attention deficit hyperactivity disorder (ADHD), especially in children who do not respond well to stimulant medications. Commonly used off-label to manage opioid withdrawal symptoms by reducing anxiety, agitation, sweating, and muscle aches. Employed in the treatment of menopausal hot flashes and certain pain conditions due to its modulatory effect on central nervous system activity. Available in oral, transdermal, and injectable forms for flexible dosing depending on the condition being treated.