Used as an oral prodrug in the treatment of bacterial infections, including respiratory tract infections like bronchitis and pneumonia, sinusitis, otitis media, urinary tract infections, and skin and skin structure infections. It is effective against a range of Gram-positive and Gram-negative bacteria. After oral administration, it is hydrolyzed to cefuroxime, the active form, which inhibits bacterial cell wall synthesis. The E-isomers refer to specific geometric configurations of the axetil ester that enhance absorption and bioavailability, contributing to the drug's overall efficacy, consistency, and broad-spectrum activity with a favorable safety profile.