Used primarily as an antifungal agent in topical formulations to treat fungal skin infections such as athlete’s foot, jock itch, and ringworm. It is also commonly found in vaginal creams for the treatment of vaginal yeast infections due to its effectiveness against Candida species. Its formulation allows for sustained activity with once-daily application, improving patient compliance. Butoconazole nitrate is favored in dermatology for its low irritation potential and high efficacy in eradicating dermatophytes and yeasts.