1,4-Bis(4-amino-6,7-dimethoxy-2-quinazolinyl)piperazine, dihydrochloride
science Other reagents with same CAS 1486464-41-8
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Used as a key intermediate in the synthesis of vardenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5), this compound plays a critical role in the development of medications for erectile dysfunction and pulmonary arterial hypertension. Its structure enables selective binding and inhibition of PDE5, enhancing smooth muscle relaxation through increased cyclic guanosine monophosphate (cGMP) levels. Due to its high specificity and efficacy, it is preferred in pharmaceutical manufacturing for producing high-purity active pharmaceutical ingredients (APIs). The dihydrochloride salt form improves solubility and stability, facilitating formulation into oral dosage forms.
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