Astragaloside IV is widely used in traditional and modern herbal medicine due to its potent biological activities. It is primarily applied for its anti-aging and anti-inflammatory effects, especially in supporting cardiovascular and immune system health. In clinical and preclinical studies, it has shown promise in protecting the heart by reducing myocardial damage and improving cardiac function after injury. It is also used to support kidney health, helping to reduce damage caused by diabetes and other chronic conditions. Another key application is in immune modulation—Astragaloside IV enhances the body’s defense mechanisms by stimulating immune cell activity and increasing resistance to infections. It is increasingly researched for its neuroprotective properties, with potential use in managing neurodegenerative diseases like Alzheimer’s by reducing oxidative stress and inflammation in brain tissues. Additionally, it is used in anti-fatigue supplements and products aimed at improving physical endurance and reducing stress. Due to its antioxidant properties, it is also incorporated into skincare formulations to combat signs of aging and promote skin repair.