Used in the management of alcohol dependence, acamprosate calcium helps restore the brain’s chemical balance after prolonged alcohol use. It reduces cravings and withdrawal symptoms by modulating glutamate neurotransmission, particularly stabilizing NMDA receptor activity that becomes dysregulated during alcohol dependence. This action supports abstinence by decreasing the urge to drink and helping patients maintain sobriety when combined with psychosocial support. It is typically prescribed as part of a comprehensive treatment program including counseling and behavioral therapies.