AKBA (Acetyl-11-keto-β-boswellic acid) is widely recognized for its potent anti-inflammatory properties, making it a key compound in natural remedies for chronic inflammatory conditions. It is commonly used in dietary supplements aimed at supporting joint health, particularly in individuals suffering from osteoarthritis and rheumatoid arthritis. AKBA works by inhibiting the 5-lipoxygenase (5-LOX) enzyme, which plays a major role in producing inflammatory mediators in the body. This mechanism helps reduce pain, swelling, and stiffness in joints. It is also being studied for its potential in supporting brain health, where it may help reduce neuroinflammation linked to cognitive decline and neurodegenerative diseases. Additionally, AKBA shows promise in gastrointestinal health, especially in managing inflammatory bowel diseases like ulcerative colitis and Crohn’s disease, due to its ability to modulate immune responses in the gut. Emerging research explores AKBA’s role in cancer support, where it may help suppress tumor growth and induce apoptosis in certain cancer cell lines, particularly in colon, prostate, and pancreatic cancers. Its ability to cross the blood-brain barrier further enhances its potential in targeting brain tumors. Due to its natural origin and relatively low toxicity, AKBA is increasingly incorporated into nutraceuticals and herbal formulations designed for long-term inflammation management.