2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

98%

Reagent Code: #110582
label
Alias Donepezil base; 1-Benzyl-4-[(5,6-dimethoxyindanon-2-yl)methyl]piperidine, donepezil
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CAS Number 120014-06-4

science Other reagents with same CAS 120014-06-4

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 379.49 g/mol
Formula C₂₄H₂₉NO₃
badge Registry Numbers
MDL Number MFCD00912833
thermostat Physical Properties
Melting Point 207°C
inventory_2 Storage & Handling
Storage room temperature

description Product Description

This compound, known as Donepezil, is a reversible acetylcholinesterase inhibitor primarily used in the treatment of mild to moderate Alzheimer's disease dementia. It works by increasing acetylcholine levels in the brain, thereby enhancing cholinergic neurotransmission and improving cognitive symptoms such as memory and thinking. The unique structure featuring a 5,6-dimethoxy-2,3-dihydroinden-1-one core linked to a 1-benzylpiperidine moiety contributes to its selectivity for brain acetylcholinesterase over butyrylcholinesterase, improving efficacy and reducing peripheral side effects. It is also investigated for potential neuroprotective effects in other neurodegenerative conditions, though its primary application remains in Alzheimer's therapy.

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Test Parameter Specification
Purity (HPLC) 98-100
Appearance Solid
Infrared Spectrum Conforms To Structure

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿9,460.00
inventory 25mg
10-20 days ฿3,500.00
inventory 1g
10-20 days ฿29,450.00
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2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
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This compound, known as Donepezil, is a reversible acetylcholinesterase inhibitor primarily used in the treatment of mild to moderate Alzheimer's disease dementia. It works by increasing acetylcholine levels in the brain, thereby enhancing cholinergic neurotransmission and improving cognitive symptoms such as memory and thinking. The unique structure featuring a 5,6-dimethoxy-2,3-dihydroinden-1-one core linked to a 1-benzylpiperidine moiety contributes to its selectivity for brain acetylcholinesterase ov

This compound, known as Donepezil, is a reversible acetylcholinesterase inhibitor primarily used in the treatment of mild to moderate Alzheimer's disease dementia. It works by increasing acetylcholine levels in the brain, thereby enhancing cholinergic neurotransmission and improving cognitive symptoms such as memory and thinking. The unique structure featuring a 5,6-dimethoxy-2,3-dihydroinden-1-one core linked to a 1-benzylpiperidine moiety contributes to its selectivity for brain acetylcholinesterase over butyrylcholinesterase, improving efficacy and reducing peripheral side effects. It is also investigated for potential neuroprotective effects in other neurodegenerative conditions, though its primary application remains in Alzheimer's therapy.

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