Norelgestromin is the active metabolite of norgestimate, widely used in combined hormonal contraceptives, particularly in transdermal patches like Ortho Evra, and also in some oral formulations. It provides a convenient and effective method for birth control by delivering a steady dose of the progestin through the skin or orally. This helps in preventing ovulation, thickening cervical mucus to block sperm, and thinning the lining of the uterus to prevent implantation.

Additionally, norelgestromin can help manage certain menstrual disorders, such as heavy or irregular periods, dysmenorrhea, and symptoms associated with polycystic ovary syndrome (PCOS). It may also reduce the risk of ectopic pregnancy when used correctly.

Its use is favored due to its stability and effectiveness in maintaining consistent hormone levels, offering a reliable option for contraception and menstrual management. Consistent use is highly effective, but consultation with a healthcare provider is recommended to assess suitability and minimize potential side effects.