Paliperidone is primarily used in the treatment of schizophrenia and schizoaffective disorder. It helps manage symptoms such as hallucinations, delusions, and disorganized thinking by regulating dopamine and serotonin levels in the brain. It is also prescribed for the maintenance treatment of bipolar I disorder to prevent mood episodes. Administered as an oral tablet or long-acting injectable, it provides sustained symptom control, improving patient adherence to treatment. Its extended-release formulation ensures steady medication levels, reducing the risk of side effects. Paliperidone is often chosen for its efficacy in managing both positive and negative symptoms of schizophrenia, contributing to improved quality of life for patients.