16α-hydroxy Estrone (16α-OHE1) is primarily studied in the context of hormonal and metabolic research. It is a metabolite of estrone, and its levels are often analyzed to assess estrogen metabolism in the body. Elevated levels of 16α-OHE1 have been associated with increased risks of certain hormone-dependent conditions, such as breast cancer, due to its potential role in promoting cell proliferation. Researchers use this metabolite as a biomarker to evaluate estrogen metabolism pathways and their implications in health and disease. Additionally, it is studied in the context of endocrine-disrupting chemicals and their effects on hormonal balance. Understanding 16α-OHE1 levels can also aid in personalized medicine approaches, particularly in tailoring hormone-related therapies or interventions.