Sulfisoxazole is primarily used as an antibacterial agent in the treatment of various infections caused by susceptible microorganisms. It is commonly prescribed for urinary tract infections due to its effectiveness in targeting common uropathogens. It may also be used in respiratory tract infections such as bronchitis, particularly when caused by susceptible strains of bacteria like Escherichia coli or Streptococcus pneumoniae. The compound is sometimes combined with other agents, such as trimethoprim, to enhance its antibacterial effect through synergistic action. This combination broadens the spectrum of activity and reduces the likelihood of bacterial resistance. Sulfisoxazole is also occasionally used in pediatric patients for the treatment of otitis media, especially in cases where penicillin allergy is present. Due to its ability to achieve good tissue penetration and adequate blood levels, it has been used in the management of certain soft tissue and systemic infections. However, its use has declined over time with the introduction of newer antibiotics and due to the risk of hypersensitivity reactions in some individuals.