Sulfisoxazole is primarily used as an antibacterial agent in the treatment of various infections. It is effective against a range of gram-positive and gram-negative bacteria. Commonly, it is prescribed for urinary tract infections due to its ability to concentrate in the urine and inhibit bacterial growth. It is also used in the management of acute exacerbations of chronic bronchitis and certain types of ear infections, especially in pediatric patients. Sulfisoxazole is often combined with other agents, such as trimethoprim, to enhance its antimicrobial effect through synergistic action. Its use has declined over time due to the availability of newer antibiotics and concerns about resistance and side effects, but it remains an option in specific clinical situations where susceptibility is confirmed.