Cefquinome sulfate is primarily used in veterinary medicine as a broad-spectrum antibiotic for the treatment of bacterial infections in animals, especially in cattle, pigs, and horses. It is effective against a wide range of Gram-positive and Gram-negative bacteria, making it a valuable choice for treating respiratory infections such as bovine respiratory disease (BRD) caused by pathogens like Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni. It is also used to treat skin and soft tissue infections in pigs, including exudative epidermitis caused by Staphylococcus hyicus. Due to its potent bactericidal action and ability to achieve high concentrations in tissues and fluids, cefquinome sulfate is often administered in cases where rapid control of severe infections is needed. The sulfate salt form enhances solubility and stability, allowing for effective intramuscular or subcutaneous injection. Its use is typically reserved for serious infections due to its classification as a third-generation cephalosporin, and it is closely monitored to prevent the development of antimicrobial resistance.