Cefquinome sulfate is primarily used in veterinary medicine as a broad-spectrum antibiotic for the treatment of bacterial infections in animals, especially in cattle, pigs, and poultry. It is effective against both Gram-positive and Gram-negative bacteria, making it suitable for treating respiratory infections such as bovine respiratory disease (BRD) in cattle, which is often associated with pathogens like Mannheimia haemolytica and Pasteurella multocida. In swine, it is used to manage respiratory and systemic infections, including those caused by Actinobacillus pleuropneumoniae and Haemophilus parasuis. Its ability to penetrate tissues effectively allows for rapid action at infection sites. The sulfate salt form enhances solubility and stability, facilitating intramuscular or subcutaneous administration. Due to its fourth-generation cephalosporin structure, cefquinome offers improved resistance to beta-lactamase enzymes produced by resistant bacteria, extending its usefulness in cases where other antibiotics may fail. It is typically reserved for serious infections and used under veterinary supervision to minimize the development of antimicrobial resistance.